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Your Number's Up is a game show that aired on NBC from September 23 to December 20, 1985. The show was hosted by Nipsey Russell with Lee Menning as co-host. Announcing duties were handled by Gene Wood for the first month and John Harlan for the rest of the run, with Johnny Haymer and Johnny Gilbert as substitutes.

This show was the first series produced by Sande Stewart, son of game show producer Bob Stewart. Your Number's Up was put up against the elder Stewart's The $25,000 Pyramid on CBS at 10:00 AM Eastern. Most of the staff from Bob Stewart Productions also worked in the production of this series.