This season, the treasure hunters depart Snake Island and continue their journey into the deepest recesses of the South American mainland to unearth priceless Inca artifacts that are part of the Treasure of the Trinity. With the elusive bounty at their fingertips, they must first survive the punishing terrain of the Atlantic Forest and the treacherous waters of the Parana River. Battling jaguars, pit vipers and venomous insects on land and piranhas, caiman and raging currents in the water, the expedition faces continuous setbacks.

Pushed to their emotional and physical limits, the team begins to wonder if the treasure is cursed due to its tangled and bloody history. The Jesuits and Guarani, custodians of the original loot through the 1700s, were continuously relocating the precious riches. In order to solve crucial historical clues, the team must design ingenious contraptions, deploy state of the art treasure hunting tools and lean on local intel. The more they follow the ancient trail of blood, the deeper they head into the most remote and dangerous parts of South America. In this uncharted realm, the team's odds of tracking down the priceless treasure are greater than ever before. But their chances of surviving the quest unscathed are next to none.